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GcvB RNA
The gcvB RNA gene encodes a small non-coding RNA involved in the regulation of a number of amino acid transport systems as well as amino acid biosynthetic genes. The GcvB gene is found in enteric bacteria such as ''Escherichia coli''. GcvB regulates genes by acting as an antisense binding partner of the mRNAs for each regulated gene. This binding is dependent on binding to a protein called Hfq protein. Transcription of the GcvB RNA is activated by the adjacent GcvA gene and repressed by the GcvR gene. A deletion of GcvB RNA from ''Y. pestis'' changed colony shape as well as reducing growth. It has been shown by gene deletion that GcvB is a regulator of acid resistance in ''E. coli''. GcvB enhances the ability of the bacterium to survive low pH by upregulating the levels of the alternate sigma factor RpoS. A polymeric form of GcvB has recently been identified.
==Targets of GcvB==
GcvB has been shown to regulate a large number of genes in ''E. coli'' and Salmonella species. GcvB was shown to bind to Oppa and DppA which transport oligopeptides and dipeptides respectively. It has been shown to also regulate gltL, argT, STM, livK, livJ, brnQ, sstT and cycA which are involved in uptake of a variety of amino acids. GcvB RNA also is involved in regulating a variety of genes involved in amino acid biosynthesis such as ilvC, gdhA, thrL and serA. GcvB RNA binds PhoPQ mRNA, whoich encodes a two-component system involved in magnesium homeostasis.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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